RYK and FZD8

Number of citations of the paper that reports this interaction (PubMedID 15454084)
146

Data Source:
HPRD (in vivo)

		RYK	FZD8
Description		receptor like tyrosine kinase	frizzled class receptor 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axonogenesis Axon Guidance Synapse Assembly Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Cell Proliferation In Midbrain Positive Regulation Of Kinase Activity Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Commissural Neuron Axon Guidance Planar Cell Polarity Pathway Involved In Axon Guidance Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation	Angiogenesis G Protein-coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT PCP/CE pathway	Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Systolic blood pressure ( 28135244 27841878)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Interacting Genes		8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A	7 interacting genes: CUL2 GOPC LRP5 LRP6 RAE1 RYK WNT1
Entrez ID		6259	8325
HPRD ID		02751	05852
Ensembl ID		ENSG00000163785	ENSG00000177283
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	Q9H461
PDB IDs			5UN5 5UN6 6NDZ
Enriched GO Terms of Interacting Partners?
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