RRM1 and NUP98

		RRM1	NUP98
Description		ribonucleotide reductase catalytic subunit M1	nucleoporin 98 and 96 precursor
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Intracellular Membrane-bounded Organelle Host Cell Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket Ribonucleoprotein Complex
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Transcription Coactivator Activity RNA Binding MRNA Binding Transporter Activity Protein Binding Nuclear Localization Sequence Binding Serine-type Peptidase Activity Structural Constituent Of Nuclear Pore Promoter-specific Chromatin Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Oxidation-reduction Process Retina Development In Camera-type Eye	Posttranscriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Viral Process Protein Sumoylation Viral Transcription Telomere Tethering At Nuclear Periphery Positive Regulation Of MRNA Splicing, Via Spliceosome Nuclear Pore Complex Assembly Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon gallium maltolate
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010) Red cell distribution width ( 27863252 28957414)	Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)
Interacting Genes		8 interacting genes: BMI1 LRIF1 NUP98 PPP1CC RNF2 RRM2 RRM2B YWHAG	30 interacting genes: APC CBFA2T3 CHMP5 CREBBP CSNK2A1 CYFIP1 EP300 HBE1 HDAC1 IPO5 KCNQ1 KPNB1 MUC2 NUP133 NUP155 NUP214 NUP62 NUP88 NXF1 PSMD13 RAE1 RCC1 RNH1 RRM1 SEC13 SLC22A18AS TNPO1 TNPO2 TPR UTRN
Entrez ID		6240	4928
HPRD ID		01588	03012
Ensembl ID		ENSG00000167325	ENSG00000110713
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	P52948
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI	1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM
Enriched GO Terms of Interacting Partners?
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