RRAS and RASIP1

Number of citations of the paper that reports this interaction (PubMedID 15031288)
32

Data Source:
HPRD (in vitro, two hybrid)

		RRAS	RASIP1
Description		RAS related	Ras interacting protein 1
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Extracellular Exosome	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)	Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Mean platelet volume ( 27863252) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		15 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1	8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2
Entrez ID		6237	54922
HPRD ID		01299	15214
Ensembl ID		ENSG00000126458	ENSG00000105538
Uniprot IDs		A0A024QZF2 P10301	Q5U651 Q7L251 Q8IUR2
PDB IDs		2FN4	5KHO 5KHQ
Enriched GO Terms of Interacting Partners?
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