RPS6KB1 and DEPTOR

Number of citations of the paper that reports this interaction (PubMedID 22017876)
104

Data Source:
BioGRID (enzymatic study)

		RPS6KB1	DEPTOR
Description		ribosomal protein S6 kinase B1	DEP domain containing MTOR interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Junction Neuron Projection Synapse	Intracellular
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Signal Transduction Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Long-chain Fatty Acid Import Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus	Negative Regulation Of Protein Kinase Activity Negative Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Cell Size Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		mTORC1-mediated signalling
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)	Choroid plexus volume ( 31530798) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549)
Interacting Genes		61 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B CYB5R3 DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MARK2 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1	12 interacting genes: APP BTRC CCDC110 CHKA CUL5 FBXO25 LNX1 PSME3 RPS6KA1 RPS6KB1 TRAF1 TRIM41
Entrez ID		6198	64798
HPRD ID		10202	13137
Ensembl ID		ENSG00000108443	ENSG00000155792
Uniprot IDs		P23443	Q8TB45
PDB IDs		3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK
Enriched GO Terms of Interacting Partners?
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