RPE65 and SLC27A1

Number of citations of the paper that reports this interaction (PubMedID 20356843)
8

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RPE65	SLC27A1
Description		retinoid isomerohydrolase RPE65	solute carrier family 27 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Body	Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Phosphatidylserine Binding Retinal Isomerase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Isomerase Activity Phosphatidylcholine Binding Metal Ion Binding Retinol Isomerase Activity All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Cardiolipin Binding	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity Protein Binding Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity
	Biological Process	Retinoid Metabolic Process Retina Homeostasis Neural Retina Development Vitamin A Metabolic Process Regulation Of Rhodopsin Gene Expression Visual Perception Circadian Rhythm Insulin Receptor Signaling Pathway Retinol Metabolic Process Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Oxidation-reduction Process Retina Morphogenesis In Camera-type Eye Cellular Response To Electrical Stimulus Zeaxanthin Biosynthetic Process	Medium-chain Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Phosphatidylcholine Biosynthetic Process Phosphatidylserine Biosynthetic Process Phosphatidylinositol Biosynthetic Process Response To Cold Positive Regulation Of Triglyceride Biosynthetic Process Long-chain Fatty Acid Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Heat Generation Cardiolipin Biosynthetic Process Response To Insulin Adiponectin-activated Signaling Pathway Long-chain Fatty Acid Import Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		The canonical retinoid cycle in rods (twilight vision)	PPARA activates gene expression Transport of fatty acids
Drugs
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Facial morphology ( 31763980) Mortality in sepsis ( 27639821) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Response to antidepressants ( 20360315)
Interacting Genes		2 interacting genes: RBP4 SLC27A1	1 interacting genes: RPE65
Entrez ID		6121	376497
HPRD ID		01569	11863
Ensembl ID		ENSG00000116745	ENSG00000130304
Uniprot IDs		Q16518	Q6PCB7
PDB IDs
Enriched GO Terms of Interacting Partners?
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