RPE65

Description		retinoid isomerohydrolase RPE65
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Body
	Molecular Function	Phosphatidylserine Binding Retinal Isomerase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Isomerase Activity Phosphatidylcholine Binding Metal Ion Binding Retinol Isomerase Activity All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Cardiolipin Binding
	Biological Process	Retinoid Metabolic Process Retina Homeostasis Neural Retina Development Vitamin A Metabolic Process Regulation Of Rhodopsin Gene Expression Visual Perception Circadian Rhythm Insulin Receptor Signaling Pathway Retinol Metabolic Process Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Oxidation-reduction Process Retina Morphogenesis In Camera-type Eye Cellular Response To Electrical Stimulus Zeaxanthin Biosynthetic Process
Pathways		The canonical retinoid cycle in rods (twilight vision)
Drugs
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Facial morphology ( 31763980) Mortality in sepsis ( 27639821) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		2 interacting genes: RBP4 SLC27A1
Entrez ID		6121
HPRD ID		01569
Ensembl ID		ENSG00000116745
Uniprot IDs		Q16518
PDB IDs
Enriched GO Terms of Interacting Partners?
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