RHEB and TSC1

Number of citations of the paper that reports this interaction (PubMedID 12820960)
336

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		RHEB	TSC1
Description		Ras homolog, mTORC1 binding	TSC complex subunit 1
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GO Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Membrane Extracellular Exosome	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Type B Pancreatic Cell Development	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases			Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		26 interacting genes: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TSC1 TSC2 USP4	47 interacting genes: AKT1 APPL2 ARAF ATXN1 AURKA BECN1 BEX3 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B DOK5 EZR FGFR4 HSH2D IKBKB KAT2A KDM1A LATS2 MAP2K5 MAPK14 MSN MYC NEFL NF2 PLK1 PLK2 PRMT6 RASSF1 RDX RHEB RIN3 SH2D2A SOX4 TBC1D7 TNS2 TSC2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		6009	7248
HPRD ID		03188	05594
Ensembl ID		ENSG00000106615	ENSG00000165699
Uniprot IDs		A0A090N900 Q15382	A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0	4Z6Y 5EJC
Enriched GO Terms of Interacting Partners?
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