RELB and NFKB2

Number of citations of the paper that reports this interaction (PubMedID 12505990)
83

Data Source:
HPRD (in vivo)

		RELB	NFKB2
Description		RELB proto-oncogene, NF-kB subunit	nuclear factor kappa B subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Centrosome Cytosol Transcriptional Repressor Complex Protein-containing Complex I-kappaB/NF-kappaB Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Kinase Binding Identical Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Stimulatory C-type Lectin Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Osmotic Stress	Negative Regulation Of Transcription By RNA Polymerase II Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK - noncanonical NF-kB signaling	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK - noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection
Drugs			Acetylsalicylic acid Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen Andrographolide
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Metabolite levels ( 23823483) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		25 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		5971	4791
HPRD ID		06886	01239
Ensembl ID		ENSG00000104856	ENSG00000077150
Uniprot IDs		D6R992 Q01201	Q00653
PDB IDs			1A3Q 2D96 3DO7 4OT9 5ZMC
Enriched GO Terms of Interacting Partners?
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