RAP1GDS1 and KIFAP3

Number of citations of the paper that reports this interaction (PubMedID 8900189)
14

Data Source:
BioGRID (pull down, two hybrid)
HPRD (two hybrid, in vitro)

		RAP1GDS1	KIFAP3
Description		Rap1 GTPase-GDP dissociation stimulator 1	kinesin associated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Condensed Nuclear Chromosome Cell Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Spindle Microtubule Cilium Axoneme Microtubule Cytoskeleton Kinesin II Complex Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Basal Body Ciliary Tip Periciliary Membrane Compartment
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Kinesin Binding Protein Phosphatase Binding Intraciliary Transport Particle B Binding
	Biological Process	Vascular Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Process Microtubule-based Movement Signal Transduction Negative Regulation Of Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Apoptotic Process Cilium Organization Positive Regulation Of Calcium-dependent Cell-cell Adhesion Protein-containing Complex Assembly Plus-end-directed Vesicle Transport Along Microtubule
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377)	Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 28416818) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: ABCB7 ANTXR2 CDC42 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS PLEKHB1 PTPRF PUF60 RAC1 RAP1A RHOA ZNF451	27 interacting genes: APC AR CCSER2 DHX37 DISC1 GTSE1 KIF3B MAP3K10 MAP3K11 MARK2 MEST MINK1 NAA10 NAV1 NCF2 NIPSNAP3A NUDT21 PARD6G PEX19 PRNP RAP1GDS1 RBFOX1 RBM14 RPGR SMC3 SRC TOR1AIP1
Entrez ID		5910	22920
HPRD ID		11763	03499
Ensembl ID		ENSG00000138698	ENSG00000075945
Uniprot IDs		B3KNU0 P52306 Q6U7G8	Q92845
PDB IDs		5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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