RAD51B and H2BC8

Number of citations of the paper that reports this interaction (PubMedID 14595808)
5

Data Source:
HPRD (in vitro)

		RAD51B	H2BC8
Description		RAD51 paralog B	H2B clustered histone 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity	DNA Binding Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Reciprocal Meiotic Recombination Blood Coagulation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Innate Immune Response In Mucosa Nucleosome Assembly Protein Ubiquitination Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation
Drugs			Copper
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Adverse response to drug ( 30420678) Age-related macular degeneration ( 23455636) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 30929738 27182965 31619474) Asthma (childhood onset) ( 31036433 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Breast cancer (male) ( 23001122) Cancer (pleiotropy) ( 27197191) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Granulocyte count ( 27863252) Heel bone mineral density ( 30598549) Height ( 31562340) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Nose size ( 27182965) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Type 2 diabetes nephropathy ( 30566433) White blood cell count ( 27863252)
Interacting Genes		10 interacting genes: ABL1 FAM9B H1-0 H2BC8 H3C1 H4C14 RAD51 RAD51C RAD51D SWSAP1	6 interacting genes: ESR1 PTMA RAD51B TGM2 UBR2 YWHAQ
Entrez ID		5890	8339
HPRD ID		04255	11897
Ensembl ID		ENSG00000182185	ENSG00000273802
Uniprot IDs		A0A024R656 C9JYJ0 O15315	B2R4S9 P62807
PDB IDs			5GT0 5KGF 6ACO 6C0W 6FML 6R0C 6RNY 6SE0 6SE6 6SEE 6SEF 6SEG
Enriched GO Terms of Interacting Partners?
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