RAD51B and H1-0

Number of citations of the paper that reports this interaction (PubMedID 4595808)
0

Data Source:
HPRD (in vitro)

		RAD51B	H1-0
Description		RAD51 paralog B	H1.0 linker histone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcriptional Repressor Complex
	Molecular Function	Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity	AT DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Reciprocal Meiotic Recombination Blood Coagulation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation Nucleosome Assembly Chromatin Silencing Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Adverse response to drug ( 30420678) Age-related macular degeneration ( 23455636) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 30929738 27182965 31619474) Asthma (childhood onset) ( 31036433 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Breast cancer (male) ( 23001122) Cancer (pleiotropy) ( 27197191) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Granulocyte count ( 27863252) Heel bone mineral density ( 30598549) Height ( 31562340) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Nose size ( 27182965) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Type 2 diabetes nephropathy ( 30566433) White blood cell count ( 27863252)
Interacting Genes		10 interacting genes: ABL1 FAM9B H1-0 H2BC8 H3C1 H4C14 RAD51 RAD51C RAD51D SWSAP1	21 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP1 PARP2 PRKCB RAD51B XBP1
Entrez ID		5890	3005
HPRD ID		04255	00819
Ensembl ID		ENSG00000182185	ENSG00000189060
Uniprot IDs		A0A024R656 C9JYJ0 O15315	P07305
PDB IDs			6HQ1 6N88 6N89
Enriched GO Terms of Interacting Partners?
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