RAB4A and IDH3A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RAB4A	IDH3A
Description		RAB4A, member RAS oncogene family	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
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GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Endomembrane System Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane	Nucleus Mitochondrion Mitochondrial Matrix
	Molecular Function	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding	Magnesium Ion Binding Isocitrate Dehydrogenase (NAD+) Activity NAD Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of ATPase Activity	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Isocitrate Metabolic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling	Citric acid cycle (TCA cycle)
Drugs			NADH Manganese Xanthinol Copper
Diseases
GWAS		Aging ( 22773346) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Eyebrow thickness ( 26926045)
Interacting Genes		31 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GDI2 GRIPAP1 HACE1 IDH3A KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830	5 interacting genes: IDH3B IDH3G MBNL1 RAB4A SUMO4
Entrez ID		5867	3419
HPRD ID		01541	03094
Ensembl ID		ENSG00000168118	ENSG00000166411
Uniprot IDs		A0A024R3U9 A0A087WYT5 P20338	B7Z9J8 P50213
PDB IDs		1YU9 1Z0K 2BMD 2BME	5GRE 5GRF 5GRH 5GRI 5GRL 5YVT 6KDE 6KDF 6KDY 6KE3
Enriched GO Terms of Interacting Partners?
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