PTPRE and KCNB1

Number of citations of the paper that reports this interaction (PubMedID 12615930)
28

Data Source:
HPRD (in vitro)

		PTPRE	KCNB1
Description		protein tyrosine phosphatase receptor type E	potassium voltage-gated channel subfamily B member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane	Cell Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Lateral Plasma Membrane Cell Junction Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Sarcolemma Perikaryon Postsynaptic Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ion Channel Binding Protein Heterodimerization Activity
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway	Action Potential Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Regulation Of Ion Transmembrane Transport Glucose Homeostasis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Regulation Of Motor Neuron Apoptotic Process
Pathways			Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Drugs		Alendronic acid	Dalfampridine
Diseases
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)
Interacting Genes		10 interacting genes: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	18 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A VAPA VAPB
Entrez ID		5791	3745
HPRD ID		02956	08983
Ensembl ID		ENSG00000132334	ENSG00000158445
Uniprot IDs		A8K2Z9 P23469 Q96P81	Q14721
PDB IDs		2JJD 6D3F 6D4D 6D4F
Enriched GO Terms of Interacting Partners?
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