KCNB1 and KCNG4

Number of citations of the paper that reports this interaction (PubMedID 12060745)
50

Data Source:
HPRD (in vivo, two hybrid)

		KCNB1	KCNG4
Description		potassium voltage-gated channel subfamily B member 1	potassium voltage-gated channel modifier subfamily G member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Lateral Plasma Membrane Cell Junction Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Sarcolemma Perikaryon Postsynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ion Channel Binding Protein Heterodimerization Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Ion Channel Binding
	Biological Process	Action Potential Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Regulation Of Ion Transmembrane Transport Glucose Homeostasis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Regulation Of Motor Neuron Apoptotic Process	Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Voltage gated Potassium channels
Drugs		Dalfampridine
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		18 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A VAPA VAPB	4 interacting genes: KCNB1 KCNB2 KCNE5 KCNF1
Entrez ID		3745	93107
HPRD ID		08983	16253
Ensembl ID		ENSG00000158445	ENSG00000168418
Uniprot IDs		Q14721	Q32MC1 Q547S7 Q8TDN1
PDB IDs
Enriched GO Terms of Interacting Partners?
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