PTPRD and PAK6

Number of citations of the paper that reports this interaction (PubMedID 22305495)
16

Data Source:
BioGRID (pull down)

		PTPRD	PAK6
Description		protein tyrosine phosphatase receptor type D	p21 (RAC1) activated kinase 6
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome Glutamatergic Synapse	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Cell Adhesion Molecule Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Presynaptic Membrane Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Regulation Of Transcription, DNA-templated Apoptotic Process Cytoskeleton Organization Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	Activation of RAC1
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Palmitic acid (16:0) levels ( 23362303) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		33 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 GPC4 IL1RAP IRS1 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS SCEL SLAIN2 SMTNL2 TBK1 TSSK2	18 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ SEMA3B SNX2 TPD52L1
Entrez ID		5789	56924
HPRD ID		03358	06426
Ensembl ID		ENSG00000153707	ENSG00000137843
Uniprot IDs		P23468 Q2HXI4 Q3KPI9 Q59H90	A0A024R9Q4 Q9NQU5
PDB IDs		1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP	2C30 2ODB 4KS7 4KS8
Enriched GO Terms of Interacting Partners?
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