PAK6 and RHOJ

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PAK6	RHOJ
Description		p21 (RAC1) activated kinase 6	ras homolog family member J
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Apoptotic Process Cytoskeleton Organization Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity	Angiogenesis Endocytosis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways		Activation of RAC1	Rho GTPase cycle
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)	Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ SEMA3B SNX2 TPD52L1	20 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 CDC42EP1 DOCK10 DOCK8 MEOX2 PAK1 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS WASL
Entrez ID		56924	57381
HPRD ID		06426	09632
Ensembl ID		ENSG00000137843	ENSG00000126785
Uniprot IDs		A0A024R9Q4 Q9NQU5	A0A024R692 Q7Z513 Q9H4E5
PDB IDs		2C30 2ODB 4KS7 4KS8
Enriched GO Terms of Interacting Partners?
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