PTPN14 and TJP1

Number of citations of the paper that reports this interaction (PubMedID 12808048)
36

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PTPN14	TJP1
Description		protein tyrosine phosphatase non-receptor type 14	tight junction protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction
	Molecular Function	Transcription Coregulator Activity Protein Tyrosine Phosphatase Activity Protein Binding Receptor Tyrosine Kinase Binding	Protein Binding Calmodulin Binding Cadherin Binding
	Biological Process	Lymphangiogenesis Protein Dephosphorylation Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Export From Nucleus Cellular Response To Cytokine Stimulus Regulation Of Nucleic Acid-templated Transcription	Cell-cell Junction Assembly Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Hippo Signaling Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways		Interleukin-37 signaling	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases		Choanal atresia and lymphedema
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Birth weight ( 31043758) Bone mineral density (hip) ( 30172743) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 28552196 25429064 31562340) Lipid traits ( 24386095) Plasma thyroid-stimulating hormone levels ( 24722205)	Central corneal thickness ( 31798171 29760442 30894546) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Interacting Genes		6 interacting genes: CDH1 CTNNA2 CTNNB1 JUP TJP1 YWHAG	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 OCLN PEA15 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		5784	7082
HPRD ID		04402	03002
Ensembl ID		ENSG00000152104	ENSG00000104067
Uniprot IDs		A8K6H6 Q15678	A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157 Q6MZU1
PDB IDs		2BZL 6IWD 6JJW	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?
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