ZNF398 and ELMO1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		ZNF398	ELMO1
Description		zinc finger protein 398	engulfment and cell motility 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Phagocytosis, Engulfment Apoptotic Process Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Regulation Of Defense Response To Virus By Virus
Pathways		Generic Transcription Pathway	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet distribution width ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210)
Interacting Genes		15 interacting genes: - C1orf109 CHPF2 CIB3 CLK2 DGCR6 ELMO1 ESR1 GPATCH2L MAGOHB MFAP1 NDE1 OPTN PLEKHF2 SMARCB1	11 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 DOCK5 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		57541	9844
HPRD ID		18336	12102
Ensembl ID		ENSG00000197024	ENSG00000155849
Uniprot IDs		A0A090N7S8 A0A090N8F2 B4DXA9 Q8TD17	A4D1X5 Q92556
PDB IDs			2RQR 2VSZ 3A98
Enriched GO Terms of Interacting Partners?
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