ZNF398 and OPTN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZNF398	OPTN
Description		zinc finger protein 398	optineurin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Perinuclear Region Of Cytoplasm Recycling Endosome Membrane
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Rab GTPase Binding Protein Binding, Bridging Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Autophagy Golgi Organization Signal Transduction Cell Death Positive Regulation Of Autophagy Viral Process Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Gram-negative Bacterium Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Golgi Ribbon Formation Positive Regulation Of Xenophagy
Pathways		Generic Transcription Pathway	Regulation of PLK1 Activity at G2/M Transition TBC/RABGAPs
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 21623375 20436471)
Interacting Genes		15 interacting genes: - C1orf109 CHPF2 CIB3 CLK2 DGCR6 ELMO1 ESR1 GPATCH2L MAGOHB MFAP1 NDE1 OPTN PLEKHF2 SMARCB1	46 interacting genes: ATG16L1 ATG5 CALM1 CDC23 DAZAP2 EPS15 FAM189A2 FLII FOS GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSPB1 HTT IRAK1 LITAF LNX2 MAP1LC3A MAP1LC3C MPP1 MYO6 PIAS4 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 SLF2 SQSTM1 TBC1D15 TBC1D17 UBC UQCRQ WASHC3 WIPI2 ZNF329 ZNF398 ZNF670
Entrez ID		57541	10133
HPRD ID		18336	03891
Ensembl ID		ENSG00000197024	ENSG00000123240
Uniprot IDs		A0A090N7S8 A0A090N8F2 B4DXA9 Q8TD17	Q96CV9
PDB IDs			2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF
Enriched GO Terms of Interacting Partners?
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