PTK7 and DUSP10

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		PTK7	DUSP10
Description		protein tyrosine kinase 7 (inactive)	dual specificity phosphatase 10
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Establishment Of Planar Polarity Ventricular Septum Development Axis Elongation Protein Phosphorylation Cell Adhesion Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Actin Cytoskeleton Reorganization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Convergent Extension Lung-associated Mesenchyme Development Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Inactivation Of MAPK Activity Regulation Of Adaptive Immune Response Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Peptidyl-threonine Dephosphorylation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways			RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer ( 25990418 20972440 24836286 29471430) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Progressive supranuclear palsy ( 30089514) Serum thyroid-stimulating hormone levels ( 25436638) Tonsillectomy ( 27182965 28928442) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		32 interacting genes: CDC14A CLNK CTDSP2 DUPD1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 ERBB2 ILKAP MTMR1 MTMR10 MTMR6 MTMR9 PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR STYX TPTE TPTE2	16 interacting genes: CMTM6 ERBB4 FHL2 FN1 HTT IGF1R MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 PTK7 ROR2 RPS11 SLX1B SNX2
Entrez ID		5754	11221
HPRD ID		03534	12320
Ensembl ID		ENSG00000112655	ENSG00000143507
Uniprot IDs		Q13308	Q9Y6W6
PDB IDs			1ZZW 2OUC 2OUD 3TG1
Enriched GO Terms of Interacting Partners?
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