GATAD2B and MBD2

Number of citations of the paper that reports this interaction (PubMedID 12183469)
34

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GATAD2B	MBD2
Description		GATA zinc finger domain containing 2B	methyl-CpG binding domain protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm NuRD Complex Nuclear Speck Protein-containing Complex	Histone Deacetylase Complex Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding Nucleosomal DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeling	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing At RDNA Methylation-dependent Chromatin Silencing Heart Development Aging Response To Mechanical Stimulus Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Cellular Protein-containing Complex Assembly Positive Regulation Of Chromatin Binding Regulation Of Cell Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Negative Regulation Of Transcription, DNA-templated Embryonic Organ Development Cellular Response To Organic Cyclic Compound
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Chronotype ( 30696823) Empathy quotient ( 29527006) General cognitive ability ( 29844566) Height ( 31562340) Lentiform nucleus volume ( 22903471) Number of children ever born ( 27798627)	Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)
Interacting Genes		20 interacting genes: CALCOCO2 CEP70 GOLGA2 H2AC20 H2BC21 H3C1 H4C1 KAT2B MBD2 MBD3 MTNR1A PRKAB2 RBPMS RPGRIP1 SMAD2 SUMO2 TEX11 TRAF1 TRIM27 USHBP1	15 interacting genes: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 RBBP4 SIN3A TBP
Entrez ID		57459	8932
HPRD ID		15094	04647
Ensembl ID		ENSG00000143614	ENSG00000134046
Uniprot IDs		Q8WXI9	A0A024R2B8 Q9UBB5
PDB IDs			2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ
Enriched GO Terms of Interacting Partners?
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