PTGIR and PDZD3

Number of citations of the paper that reports this interaction (PubMedID 22884631)
1

Data Source:
BioGRID (two hybrid, affinity chromatography technology, imaging technique)

		PTGIR	PDZD3
Description		prostaglandin I2 receptor	PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Intestinal infectious diseases
Drugs		Treprostinil Iloprost Dinoprost Tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		5739	79849
HPRD ID		08959	06191
Ensembl ID		ENSG00000160013	ENSG00000172367
Uniprot IDs		P43119	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?
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