PTGFR and PTGDS

Number of citations of the paper that reports this interaction (PubMedID 8300593)
40

Data Source:
HPRD (in vivo)

		PTGFR	PTGDS
Description		prostaglandin F receptor	prostaglandin D2 synthase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Prostaglandin F Receptor Activity	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Prostaglandin Biosynthetic Process Cyclooxygenase Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost Tromethamine Tafluprost Latanoprostene Bunod
Diseases
GWAS		Bipolar disorder ( 22182935) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Beta-trace protein levels ( 23328707) Blood protein levels ( 30072576 29875488) Corneal structure ( 23291589)
Interacting Genes		5 interacting genes: AGTR1 PTGDS PTGER1 PTGER2 PTGES2	17 interacting genes: AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 MLH1 PTGER1 PTGER2 PTGFR SHBG
Entrez ID		5737	5730
HPRD ID		08988	08904
Ensembl ID		ENSG00000122420	ENSG00000107317
Uniprot IDs		P43088	A0A024R8G3 P41222
PDB IDs			2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9
Enriched GO Terms of Interacting Partners?
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