CBX8 and MLLT1

Number of citations of the paper that reports this interaction (PubMedID 15856011)
39

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		CBX8	MLLT1
Description		chromobox 8	MLLT1 super elongation complex subunit
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GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex
	Molecular Function	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		General risk tolerance (MTAG) ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258)	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)
Interacting Genes		36 interacting genes: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 H3-4 HAP1 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF5 PNMA2 RING1 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14	11 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 H1-5 H3-4 MLLT10 PAF1 WDR5
Entrez ID		57332	4298
HPRD ID		13006	15933
Ensembl ID		ENSG00000141570	ENSG00000130382
Uniprot IDs		Q9HC52	Q03111
PDB IDs		2N4Q 3I91 5EQ0	5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O
Enriched GO Terms of Interacting Partners?
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