CBX8 and MTUS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CBX8	MTUS2
Description		chromobox 8	microtubule associated scaffold protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Cytoplasm Centrosome Cytoplasmic Microtubule
	Molecular Function	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity	Protein Binding Microtubule Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258)	Insomnia (caffeine-induced) ( 22754043) Obesity-related traits ( 23251661) Triptolide cytotoxicity ( 26121980)
Interacting Genes		36 interacting genes: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 H3-4 HAP1 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF5 PNMA2 RING1 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14	181 interacting genes: - AEN AFF4 AKT1 AQP1 ARNT2 AXIN1 BCL6 BMP7 BYSL C1orf109 C1orf216 C21orf58 C2CD6 C8orf34 CATIP CATSPER1 CBX8 CCDC116 CCDC146 CCDC17 CCDC198 CCDC60 CCHCR1 CDC20B CDC73 CDK18 CDK5R1 CDKL3 CEP57L1 CEP95 CERK COG2 CREB5 CRY2 CTSZ CWF19L2 CXCL11 CXCL16 DCDC2B DCTN4 DLGAP5 DMRT3 DOCK2 DTNB FAM110A FAM13C FAM161A FAM71E2 FAM74A4 FAM90A1 FBXL18 FBXO34 FCHSD2 FHL3 FNDC11 GAL3ST2 GOLGA2P11 GRAP2 GTF2I GTPBP10 HAUS1 HCK HDAC4 HSF2 IQCE ITGB5 ITSN1 KAT5 KIF1A KRT6A LENG1 LIMS2 LINC00636 LMO2 LNX1 LRR1 LYSMD1 MAGEA8 MARK4 MFAP1 MRPL11 MTMR6 NDEL1 NDOR1 NEFL NELFE NTAQ1 NUBPL NUDT10 ODF1 PDE4DIP PIN1 PKP2 PLK4 PLSCR4 POLDIP2 POLDIP3 PPHLN1 PPP1R18 PRKAA1 PRPF31 PSMA1 PTPMT1 RAB3IL1 RGS2 RHPN1 RIBC2 RNF6 ROBO3 RPA1 RPL9 RTP5 SCEL SCNM1 SDCBP SELENOM SETD5 SH2D4A SH3RF2 SHFL SLC23A1 SLC25A6 SLIRP SMARCE1 SNAI1 SNHG11 SNRPA SNRPB2 SNW1 SPATA8 SPG7 STK16 SYT6 TAF13 TEAD4 THAP7 TLE5 TP53RK TRIM42 TSGA10IP TSHZ3 TULP2 TXN2 USP2 WAC ZBTB38 ZC2HC1C ZFC3H1 ZFP2 ZFP64 ZFYVE21 ZMAT2 ZNF136 ZNF20 ZNF224 ZNF232 ZNF250 ZNF3 ZNF329 ZNF337 ZNF410 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF490 ZNF557 ZNF572 ZNF581 ZNF587 ZNF599 ZNF607 ZNF624 ZNF655 ZNF670 ZNF785 ZNF844 ZSCAN12 ZSCAN26
Entrez ID		57332	23281
HPRD ID		13006	11108
Ensembl ID		ENSG00000141570	ENSG00000132938
Uniprot IDs		Q9HC52	J3KQA9 Q5JR59
PDB IDs		2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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