PRTFDC1 and HPRT1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		PRTFDC1	HPRT1
Description		phosphoribosyl transferase domain containing 1	hypoxanthine phosphoribosyltransferase 1
Image
GO Annotations	Cellular Component		Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Identical Protein Binding Guanine Phosphoribosyltransferase Activity
	Biological Process	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Purine-containing Compound Salvage Hypoxanthine Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization
Pathways			Purine salvage
Drugs			Azathioprine Mercaptopurine Alpha-Phosphoribosylpyrophosphoric Acid 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol 9-Deazaguanine
Diseases			Lesch-Nyhan syndrome; Hypoxanthine-guanine phosophoribosyltransferase deficiency
GWAS		Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Intraocular pressure ( 29617998) Lymphocyte counts ( 27863252) Metabolite levels (Pyroglutamine) ( 23934736) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity-related traits ( 23251661) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Platelet count ( 27863252) Plateletcrit ( 27863252) Post-traumatic stress disorder ( 25456346) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		14 interacting genes: DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B MCMBP NIF3L1 RAB18 STAT5A TCL1A TMEM14B	6 interacting genes: FANCA ISCU NTAQ1 PCNT PRTFDC1 SDCBP
Entrez ID		56952	3251
HPRD ID		17917	02388
Ensembl ID		ENSG00000099256	ENSG00000165704
Uniprot IDs		Q9NRG1	A0A140VJL3 P00492
PDB IDs		2JBH	1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ
Enriched GO Terms of Interacting Partners?
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