HPRT1 and FANCA

Number of citations of the paper that reports this interaction (PubMedID 14499622)
12

Data Source:
BioGRID (two hybrid)

		HPRT1	FANCA
Description		hypoxanthine phosphoribosyltransferase 1	FA complementation group A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Identical Protein Binding Guanine Phosphoribosyltransferase Activity	Protein Binding
	Biological Process	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Purine-containing Compound Salvage Hypoxanthine Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization	DNA Repair Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Cell Proliferation Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex Assembly Regulation Of CD40 Signaling Pathway
Pathways		Purine salvage	Fanconi Anemia Pathway
Drugs		Azathioprine Mercaptopurine Alpha-Phosphoribosylpyrophosphoric Acid 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol 9-Deazaguanine
Diseases		Lesch-Nyhan syndrome; Hypoxanthine-guanine phosophoribosyltransferase deficiency	Fanconi anemia
GWAS		Estimated glomerular filtration rate ( 31015462)	Hair morphology traits ( 30166351) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 31959993 30054594) Low tan response ( 29739929) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)
Interacting Genes		6 interacting genes: FANCA ISCU NTAQ1 PCNT PRTFDC1 SDCBP	48 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		3251	2175
HPRD ID		02388	06186
Ensembl ID		ENSG00000165704	ENSG00000187741
Uniprot IDs		A0A140VJL3 P00492	O15360
PDB IDs		1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ
Enriched GO Terms of Interacting Partners?
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