TRIM39 and USP5

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		TRIM39	USP5
Description		tripartite motif containing 39	ubiquitin specific peptidase 5
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GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol	Lysosome Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)
Interacting Genes		55 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMD9 RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1 UBTD2 UBXN1 UBXN6 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	23 interacting genes: APP CACNA1H DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 SMURF1 STK33 TADA3 TMEM239 TRAF6 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIML1 UBE2S UBTD2 USP28
Entrez ID		56658	8078
HPRD ID		09298	03265
Ensembl ID		ENSG00000204599	ENSG00000111667
Uniprot IDs		A0A024RCP5 A0A024RCR1 Q9HCM9	A0A140VJZ1 P45974
PDB IDs		2DID 2DIF 2ECJ	2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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