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USP5

Description ubiquitin specific peptidase 5
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GO Annotations Cellular Component
  • Lysosome
  • Cytosol
Molecular Function
  • Cysteine-type Endopeptidase Activity
  • Thiol-dependent Ubiquitin-specific Protease Activity
  • Protein Binding
  • Zinc Ion Binding
  • Thiol-dependent Ubiquitinyl Hydrolase Activity
  • Ubiquitin Binding
Biological Process
  • Ubiquitin-dependent Protein Catabolic Process
  • Protein Ubiquitination
  • Protein Deubiquitination
  • Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
  • Protein K48-linked Deubiquitination
Pathways
  • Ub-specific processing proteases
  • Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS
Interacting Genes 23 interacting genes: APP CACNA1H DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 SMURF1 STK33 TADA3 TMEM239 TRAF6 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIML1 UBE2S UBTD2 USP28
Entrez ID 8078
HPRD ID 03265
Ensembl ID ENSG00000111667
Uniprot IDs A0A140VJZ1 P45974
PDB IDs 2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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