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POLE4 and POLE
Number of citations of the paper that reports this interaction (PubMedID
10801849
)
27
Data Source:
HPRD
(in vitro)
POLE4
POLE
Description
DNA polymerase epsilon 4, accessory subunit
DNA polymerase epsilon, catalytic subunit
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Epsilon DNA Polymerase Complex
Nucleus
Nucleoplasm
Plasma Membrane
Epsilon DNA Polymerase Complex
Molecular Function
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Protein Heterodimerization Activity
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity
4 Iron, 4 Sulfur Cluster Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
DNA Replication Initiation
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication Initiation
Leading Strand Elongation
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
DNA Replication Proofreading
Embryonic Organ Development
Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Drugs
Cladribine
Cladribine
Diseases
GWAS
Body mass index (
26426971
)
Metabolite levels (
23823483
)
Urate levels in overweight individuals (
25811787
)
Interacting Genes
6 interacting genes:
HSPA13
NFYB
POLE
POLE2
POLE3
UBE3A
12 interacting genes:
GINS4
MDM2
PCNA
POLA1
POLD4
POLE2
POLE4
RAD17
SCARB1
STK19
TOPBP1
XRCC5
Entrez ID
56655
5426
HPRD ID
16238
07177
Ensembl ID
ENSG00000115350
ENSG00000177084
Uniprot IDs
Q9NR33
Q07864
PDB IDs
5VBN
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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