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POLE4

Description DNA polymerase epsilon 4, accessory subunit
Image No pdb structure
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Ada2/Gcn5/Ada3 Transcription Activator Complex
  • Epsilon DNA Polymerase Complex
Molecular Function
  • DNA Binding
  • DNA-directed DNA Polymerase Activity
  • Protein Binding
  • Protein Heterodimerization Activity
Biological Process
  • G1/S Transition Of Mitotic Cell Cycle
  • DNA Replication Initiation
  • Telomere Maintenance Via Semi-conservative Replication
  • DNA Biosynthetic Process
Pathways
  • Recognition of DNA damage by PCNA-containing replication complex
  • PCNA-Dependent Long Patch Base Excision Repair
  • Termination of translesion DNA synthesis
  • HDR through Homologous Recombination (HRR)
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • DNA replication initiation
  • Activation of the pre-replicative complex
Drugs
  • Cladribine
Diseases
GWAS
Interacting Genes 6 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 UBE3A
Entrez ID 56655
HPRD ID 16238
Ensembl ID ENSG00000115350
Uniprot IDs Q9NR33
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025

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