AXL and PIK3R3

Number of citations of the paper that reports this interaction (PubMedID 12470648)
34

Data Source:
HPRD (two hybrid)

		AXL	PIK3R3
Description		AXL receptor tyrosine kinase	phosphoinositide-3-kinase regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Actin Cytoskeleton Intracellular Membrane-bounded Organelle Receptor Complex Host Cell Surface Extracellular Exosome	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Virus Receptor Activity Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Positive Regulation Of Kinase Activity Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Negative Regulation Of Dendritic Cell Apoptotic Process	Positive Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation
Pathways		VEGFA-VEGFR2 Pathway	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL
Drugs			Isoprenaline SF1126
Diseases
GWAS		HDL cholesterol ( 31170924) Heel bone mineral density ( 30598549)	Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Breast cancer ( 29059683) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Sodium levels ( 29403010) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		23 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3	81 interacting genes: ABCB6 ABL2 AMBP ANKS1A AUNIP AXL BRK1 BTK CAMK1 CCDC14 CCDC33 CEP126 CEP19 CLNK CRBN CRK DARS1 DCAF8 DRAP1 DSN1 E2F6 EGFR ERBB2 ERBB3 ESR1 FBN3 FER FGB FOXO1 FSD2 FYN GC HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 KARS1 KHDRBS1 KLC2 KLF15 KMT2B L3MBTL3 LNX2 LUC7L2 MBIP MECOM MICAL1 MTF2 NCK1 ORM1 PACRGL PCDHB5 PDGFRB PELO PIK3CA PLB1 PPARA PSME1 QARS1 RB1 RING1 SERF1A SOCS6 SRC STAT3 TEC TERF2 TNNC2 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 ZMAT1 ZNF281 ZNF451
Entrez ID		558	8503
HPRD ID		00171	05831
Ensembl ID		ENSG00000167601	ENSG00000117461
Uniprot IDs		M0R0W6 P30530	B4DXM8 Q68CY7 Q7Z3W2 Q8N381 Q92569
PDB IDs		2C5D 4RA0 5U6B 5VXZ
Enriched GO Terms of Interacting Partners?
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