AXL and IL2RG

Number of citations of the paper that reports this interaction (PubMedID 16308569)
18

Data Source:
HPRD (in vivo)

		AXL	IL2RG
Description		AXL receptor tyrosine kinase	interleukin 2 receptor subunit gamma
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Actin Cytoskeleton Intracellular Membrane-bounded Organelle Receptor Complex Host Cell Surface Extracellular Exosome	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Virus Receptor Activity Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Positive Regulation Of Kinase Activity Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Negative Regulation Of Dendritic Cell Apoptotic Process	MAPK Cascade Immune Response Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		VEGFA-VEGFR2 Pathway	Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Resatorvid
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		HDL cholesterol ( 31170924) Heel bone mineral density ( 30598549)
Interacting Genes		23 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3	25 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		558	3561
HPRD ID		00171	02391
Ensembl ID		ENSG00000167601	ENSG00000147168
Uniprot IDs		M0R0W6 P30530	P31785
PDB IDs		2C5D 4RA0 5U6B 5VXZ	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL
Enriched GO Terms of Interacting Partners?
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