ARHGEF40 and STC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARHGEF40	STC2
Description		Rho guanine nucleotide exchange factor 40	stanniocalcin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Extracellular Space Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Hormone Activity Enzyme Binding Heme Binding Protein Homodimerization Activity
	Biological Process		Cellular Calcium Ion Homeostasis Response To Oxidative Stress Embryo Implantation Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Response To Vitamin D Negative Regulation Of Multicellular Organism Growth Response To Peptide Hormone Post-translational Protein Modification Cellular Protein Metabolic Process Decidualization Regulation Of Hormone Biosynthetic Process Cellular Response To Hypoxia Regulation Of Store-operated Calcium Entry
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Hematocrit ( 27863252) Pediatric nonalcoholic steatohepatitis ( 28918882) Resting heart rate ( 27798624)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Height ( 25429064 31562340) Immunoglobulin A vasculitis ( 28698626) Prostate cancer ( 23535732) Urate levels in overweight individuals ( 25811787)
Interacting Genes		6 interacting genes: APP CBY2 MAPT MYCBP STC2 TAC1	20 interacting genes: ADAM11 AIFM1 ARHGEF40 ARRB2 CARHSP1 CELF6 CPN1 EIF2B3 ELOB ERGIC1 FAF2 FGFR4 HK3 PEBP1 PLA2G5 POLR2C POLR3F PPP1R8 PTN RNF44
Entrez ID		55701	8614
HPRD ID		13335	04717
Ensembl ID		ENSG00000165801	ENSG00000113739
Uniprot IDs		Q8TER5	O76061 Q6FHC9
PDB IDs
Enriched GO Terms of Interacting Partners?
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