VAC14 and ZCWPW1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		VAC14	ZCWPW1
Description		VAC14 component of PIKFYVE complex	zinc finger CW-type and PWWP domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extrinsic Component Of Vacuolar Membrane Vacuolar Membrane Endoplasmic Reticulum Cytosol Endosome Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle PAS Complex
	Molecular Function	Protein Binding Signaling Receptor Activity	Zinc Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Viral Process Positive Regulation Of Kinase Activity
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pulse pressure ( 28135244)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Family history of Alzheimer's disease ( 30617256) Platelet distribution width ( 27863252) Plateletcrit ( 27863252)
Interacting Genes		53 interacting genes: ACSS1 APP ASB13 BCL2L1 BHLHE40 C11orf54 C4orf33 CASP1 CCDC103 CD209 CDRT4 CNTN2 COL8A1 CRK DDAH2 FNDC3B GALT GINS3 HNRNPLL JMJD7 KRTAP19-5 KRTAP19-7 KYAT1 LINC00518 LPAL2 MGAT5B MPPED2 MTMR9 MVP NGB NOS1 NTAQ1 PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PRADC1 PRR13 PRR20A RBFOX2 RHOXF2 SIGLEC5 SMUG1 SNF8 SPRYD7 SRPK2 TCEANC TP53BP1 ZCWPW1 ZNF34	3 interacting genes: L3MBTL3 MEOX2 VAC14
Entrez ID		55697	55063
HPRD ID		07660	15706
Ensembl ID		ENSG00000103043	ENSG00000078487
Uniprot IDs		Q08AM6	Q9H0M4
PDB IDs			2E61 2RR4
Enriched GO Terms of Interacting Partners?
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