PNRC2 and ESRRA

Number of citations of the paper that reports this interaction (PubMedID 11574675)
17

Data Source:
HPRD (in vivo, two hybrid)

		PNRC2	ESRRA
Description		proline rich nuclear receptor coactivator 2	estrogen related receptor alpha
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Golgi Apparatus Cytosol	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Mitochondrion Organization Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Cell Proliferation Steroid Hormone Mediated Signaling Pathway Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Positive Regulation Of Cellular Response To Insulin Stimulus
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity
Drugs			Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
Diseases
GWAS		Obesity-related traits ( 23251661)	Crohn's disease ( 28067908 21102463) Vitiligo ( 27723757)
Interacting Genes		21 interacting genes: APP AR DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48	31 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARGC1A PRKCD PROX1 PSMC5 SIRT1 SMARCD3 SP1 TNNI2
Entrez ID		55629	2101
HPRD ID		17871	07210
Ensembl ID		ENSG00000189266	ENSG00000173153
Uniprot IDs		Q9NPJ4	P11474 Q569H8
PDB IDs		4B6H 5KQ1 5KQ4	1XB7 2PJL 3D24 3K6P
Enriched GO Terms of Interacting Partners?
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