ESRRA and MACF1

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ESRRA	MACF1
Description		estrogen related receptor alpha	microtubule actin crosslinking factor 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Ruffle Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Sequence-specific DNA Binding	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding ATPase Activity Cadherin Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Mitochondrion Organization Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Cell Proliferation Steroid Hormone Mediated Signaling Pathway Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Positive Regulation Of Cellular Response To Insulin Stimulus	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly Regulation Of Neuron Projection Arborization
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity
Drugs		Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Vitiligo ( 27723757)	Beard thickness ( 26926045) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 25961943 20686565) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Type 2 diabetes ( 27189021 30054458 29358691 30297969 29632382 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		31 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARGC1A PRKCD PROX1 PSMC5 SIRT1 SMARCD3 SP1 TNNI2	27 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 GOLGA4 JUN MAPK9 MAPRE1 MTNR1B NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL SRPK2 TANGO6 TNIK TRAF3IP1 UBC
Entrez ID		2101	23499
HPRD ID		07210	09750
Ensembl ID		ENSG00000173153	ENSG00000127603
Uniprot IDs		P11474 Q569H8	Q6ZSD7 Q9UPN3
PDB IDs		1XB7 2PJL 3D24 3K6P	4Z6G 5VE9 5X57
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?