PRKAA1 and ZBED1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PRKAA1	ZBED1
Description		protein kinase AMP-activated catalytic subunit alpha 1	zinc finger BED-type containing 1
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Neuronal Cell Body	Nuclear Chromatin Nucleoplasm Centrosome Nuclear Membrane
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Histone Serine Kinase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding SUMO Transferase Activity Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Macroautophagy Regulation Of Macroautophagy Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Energy Homeostasis Response To Camptothecin Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Cellular Protein Localization Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Peptidyl-lysine Acetylation	Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs	SUMOylation of chromatin organization proteins
Drugs		Adenosine monophosphate ATP Phenformin Acetylsalicylic acid
Diseases
GWAS		Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Non-cardia gastric cancer ( 26701879 26129866)
Interacting Genes		67 interacting genes: ABI2 ACACA BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TLE5 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1	29 interacting genes: AMOTL2 ATRX C1orf109 DGCR6 EFHC1 FABP4 FANCG GPN1 GPSM1 KDM1A KLHL40 LRRC20 MLH1 NIF3L1 NIP7 NUDT18 PIAS2 PRKAA1 PRKAR1A PSAP RENBP SORBS3 SPEF1 SSX2 SUMO2 TRAPPC2B TTR UBE2I UCHL5
Entrez ID		5562	9189
HPRD ID		04115	02170
Ensembl ID		ENSG00000132356	ENSG00000214717
Uniprot IDs		Q13131	A0A024RBU4 O96006
PDB IDs		4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J	2CT5
Enriched GO Terms of Interacting Partners?
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