PRKAA1 and STK11

Number of citations of the paper that reports this interaction (PubMedID 16912160)
21

Data Source:
BioGRID (enzymatic study)

		PRKAA1	STK11
Description		protein kinase AMP-activated catalytic subunit alpha 1	serine/threonine kinase 11
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Histone Serine Kinase Activity Protein-containing Complex Binding Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau Protein Binding Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Macroautophagy Regulation Of Macroautophagy Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Rhythmic Process Positive Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Lipid Catabolic Process Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Motor Behavior CAMKK-AMPK Signaling Cascade Regulation Of Stress Granule Assembly Neuron Cellular Homeostasis Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Energy Homeostasis Response To Camptothecin Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitochondrial Transcription Positive Regulation Of Cellular Protein Localization Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Peptidyl-lysine Acetylation	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatogenesis Axonogenesis Negative Regulation Of Cell Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Establishment Of Cell Polarity Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling
Pathways		Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes
Drugs		Adenosine monophosphate ATP Phenformin Acetylsalicylic acid
Diseases			Peutz-Jeghers syndrome Pancreatic cancer
GWAS		Cardia gastric cancer ( 26129866) Gastric cancer ( 22037551 26098866 26129866 31383772) Non-cardia gastric cancer ( 26701879 26129866)	Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Psychosis in Alzheimer's disease ( 22005930)
Interacting Genes		67 interacting genes: ABI2 ACACA BHLHE40 CAB39 CAMKK1 CDX4 CFTR CHEK1 CRTC2 CTBP1 DVL2 EEF2K EPM2A FANCA FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KIF16B KRT40 L3MBTL3 MDM4 MORC4 MTOR MTUS2 PASK PFKFB2 PHC2 PNMA5 PPM1A PPM1E PPM1F PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RACK1 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TLE5 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 ULK1 VPS37B VPS52 ZBED1	113 interacting genes: ABCB5 ADIPOR1 AKT1 APP ARAF ARG2 ARNT ATM AURKA BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCND2 CCNE1 CD44 CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A KAT2A KDELR2 KLK7 LATS2 LYPD3 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB TBC1D23 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 YWHAG
Entrez ID		5562	6794
HPRD ID		04115	03740
Ensembl ID		ENSG00000132356	ENSG00000118046
Uniprot IDs		Q13131	A0A0S2Z4D1 Q15831
PDB IDs		4RED 4RER 4REW 5EZV 6C9F 6C9G 6C9H 6C9J	2WTK 4ZDR 5WXN
Enriched GO Terms of Interacting Partners?
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