PPT1 and RLF

		PPT1	RLF
Description		palmitoyl-protein thioesterase 1	RLF zinc finger
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Lysosome Golgi Apparatus Cytosol Synaptic Vesicle Membrane Axon Dendrite Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome	Nucleus
	Molecular Function	Protein Binding Palmitoyl-(protein) Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Thiolester Hydrolase Activity Lysophosphatidic Acid Binding Sulfatide Binding	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Protein Depalmitoylation Receptor-mediated Endocytosis Pinocytosis Lysosomal Lumen Acidification Neurotransmitter Secretion Nervous System Development Brain Development Visual Perception Grooming Behavior Associative Learning Adult Locomotory Behavior Protein Transport Lipid Catabolic Process Sphingolipid Catabolic Process Protein Catabolic Process Negative Regulation Of Cell Growth Membrane Raft Organization Regulation Of Phospholipase A2 Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Pinocytosis Neuron Development Regulation Of Synapse Structure Or Activity Response To Stimulus Cofactor Transport Cofactor Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II DNA Integration Regulation Of DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Chromosome Organization Histone H3-K4 Monomethylation
Pathways		Fatty acyl-CoA biosynthesis
Drugs		1-Hexadecylsulfonyl Fluoride Palmitic Acid
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels ( 30072576 29875488)	High density lipoprotein cholesterol levels ( 30498476) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		4 interacting genes: COL6A3 EPS15 GNAQ RLF	7 interacting genes: CLK1 GCH1 PPT1 PRPF40A RIT1 RIT2 TRIM14
Entrez ID		5538	6018
HPRD ID		07203	01614
Ensembl ID		ENSG00000131238	ENSG00000117000
Uniprot IDs		P50897	Q13129
PDB IDs		3GRO
Enriched GO Terms of Interacting Partners?
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