PPT1 and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PPT1	GNAQ
Description		palmitoyl-protein thioesterase 1	G protein subunit alpha q
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Lysosome Golgi Apparatus Cytosol Synaptic Vesicle Membrane Axon Dendrite Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome
	Molecular Function	Protein Binding Palmitoyl-(protein) Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Thiolester Hydrolase Activity Lysophosphatidic Acid Binding Sulfatide Binding	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Protein Depalmitoylation Receptor-mediated Endocytosis Pinocytosis Lysosomal Lumen Acidification Neurotransmitter Secretion Nervous System Development Brain Development Visual Perception Grooming Behavior Associative Learning Adult Locomotory Behavior Protein Transport Lipid Catabolic Process Sphingolipid Catabolic Process Protein Catabolic Process Negative Regulation Of Cell Growth Membrane Raft Organization Regulation Of Phospholipase A2 Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Protein Catabolic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Pinocytosis Neuron Development Regulation Of Synapse Structure Or Activity Response To Stimulus Cofactor Transport Cofactor Metabolic Process	Action Potential Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Positive Regulation Of GTPase Activity Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway
Pathways		Fatty acyl-CoA biosynthesis	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		1-Hexadecylsulfonyl Fluoride Palmitic Acid
Diseases		Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Blood protein levels ( 30072576 29875488)	Bipolar disorder ( 31043756)
Interacting Genes		4 interacting genes: COL6A3 EPS15 GNAQ RLF	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		5538	2776
HPRD ID		07203	02998
Ensembl ID		ENSG00000131238	ENSG00000156052
Uniprot IDs		P50897	A0A024R240 P50148
PDB IDs		3GRO
Enriched GO Terms of Interacting Partners?
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