PPP4C and TRIM28

Number of citations of the paper that reports this interaction (PubMedID 22491012)
44

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PPP4C	TRIM28
Description		protein phosphatase 4 catalytic subunit	tripartite motif containing 28
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Protein Phosphatase 4 Complex	Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Protein-containing Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Dephosphorylation Regulation Of Double-strand Break Repair Via Homologous Recombination NIK/NF-kappaB Signaling	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Ras Protein Signal Transduction Embryo Implantation Viral Process Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus DNA Methylation Involved In Embryo Development Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Positive Regulation Of Methylation-dependent Chromatin Silencing Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting
Pathways		Processing of DNA double-strand break ends	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Schizophrenia ( 25056061 29483656)
Interacting Genes		21 interacting genes: CCDC6 DHX38 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA RPA2 TIPRL TK1 TMSB4X TP53 TRAF6 TRIM28	70 interacting genes: CBX1 CBX3 CBX5 CDC34 CDCA4 CDKN2A CEBPB CHAF1A CHD3 ESR1 EZH2 FBP1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA6 MAGED1 MAPKAPK2 MYB NPM1 NR3C1 NR4A1 NR4A3 NSMCE3 PFDN5 PPP2CA PPP4C RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74
Entrez ID		5531	10155
HPRD ID		03615	03445
Ensembl ID		ENSG00000149923	ENSG00000130726
Uniprot IDs		A0A024R625 P60510	Q13263
PDB IDs			1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1
Enriched GO Terms of Interacting Partners?
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