TRIM28 and CDKN2A

Number of citations of the paper that reports this interaction (PubMedID 26055329)
11

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, imaging technique, pull down)

		TRIM28	CDKN2A
Description		tripartite motif containing 28	cyclin dependent kinase inhibitor 2A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Protein-containing Complex RNA Polymerase II Transcription Factor Complex	Nucleus Cytoplasm Cytosol Senescence-associated Heterochromatin Focus
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding	RNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Ras Protein Signal Transduction Embryo Implantation Viral Process Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus DNA Methylation Involved In Embryo Development Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Positive Regulation Of Methylation-dependent Chromatin Silencing Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell-matrix Adhesion Cell Cycle Arrest Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Cellular Senescence Replicative Senescence Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Senescence
Pathways		Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Transcriptional Regulation by VENTX Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Apoptotic factor-mediated response Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Stabilization of p53 Regulation of RUNX3 expression and activity Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Drugs
Diseases			Bladder cancer Type II diabetes mellitus Pancreatic cancer Burkitt lymphoma Adult T-cell leukemia Malignant pleural mesothelioma Non-small cell lung cancer Chronic myeloid leukemia (CML) Oral cancer Penile cancer Nasopharyngeal cancer Glioma Osteosarcoma Squamous cell carcinoma Cholangiocarcinoma Gallbladder cancer Malignant islet cell carcinoma Laryngeal cancer Hepatocellular carcinoma Esophageal cancer Malignant melanoma
GWAS			Abdominal aortic aneurysm ( 20622881) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 24403052 25855136) Breast cancer ( 29059683 23535729 20453838) Coronary artery calcification ( 23561647) Coronary artery disease ( 21239051 29263402 26708285) Coronary heart disease ( 21971053 17554300 21378990) Coronary heart disease (SNP X SNP interaction) ( 21626137) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Fasting plasma glucose ( 25187374) Glioblastoma ( 28346443) Glioma ( 28346443 21531791 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Lymphocyte counts ( 27863252) Melanoma ( 21983787 28212542 19578364) Monocyte count ( 27863252) Multiple myeloma ( 27363682) Myocardial infarction ( 17478679 26708285) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 26545403) Non-glioblastoma glioma ( 28346443) Non-small cell lung cancer ( 31326317) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Platelet count ( 22139419 27863252) Plateletcrit ( 27863252) Type 2 diabetes ( 21573907 27189021 18372903 24509480 26961502 29358691 30297969 26818947 23945395 20581827 19401414 17463246 30718926 17463248 17463249 23209189) White blood cell count ( 27863252)
Interacting Genes		70 interacting genes: CBX1 CBX3 CBX5 CDC34 CDCA4 CDKN2A CEBPB CHAF1A CHD3 ESR1 EZH2 FBP1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA6 MAGED1 MAPKAPK2 MYB NPM1 NR3C1 NR4A1 NR4A3 NSMCE3 PFDN5 PPP2CA PPP4C RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74	150 interacting genes: - ACLY ACTB ACTG1 ACTN4 AHNAK AKT1 ANAPC15 ANGPTL4 ANKRA2 ANKRD12 ARFIP2 ARNT ASPRV1 AZIN1 BCL2L1 BECN1 CARF CASC3 CCDC183 CCND2 CCNDBP1 CCNE1 CCNG1 CD44 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2B CDKN2C CENPA CRELD2 CTBP2 DEAF1 E2F1 E4F1 EEF2 EFHC2 EGR1 EPHA2 EPHA3 EXOC2 FGFR4 FN1 FZR1 GAPDH GGA1 GGA3 GLIS1 GLIS2 GMNN GSPT1 H2BU1 HGF HIF1A HLA-DOB HNRNPA2B1 HNRNPC HNRNPU HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 ISOC2 KAT5 LAMTOR3 LATS2 MAF1 MAP2K5 MAP3K5 MAPK10 MAPK14 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MDM4 MMRN1 MTR MYC MYL12A NAT2 NCL NMI NOP53 NPM1 NSD3 ORC4 PCNA PDCD6 PDGFRA PEX19 PPP1R9B PRKCA PSMC3 PTP4A3 RAF1 RASSF1 RBM26 RIN2 RPL11 RPS7 RUVBL2 SERTAD1 SIVA1 SIX2 SLC4A1 SMARCA4 SNRPA SNRPB SOX3 SOX4 STK11 TBRG1 TDRD7 TEAD2 TERT TFDP1 TP53 TP63 TPI1 TRIM28 TRIP12 TSC1 TUBA1A TUBA1C TUBB TUBB4B UBE2A UBE4B UBL7 USP26 VAMP1 VHL WRN YY1 ZFP91 ZGRF1 ZNF227 ZNF410 ZNF420 ZNF687 ZUP1
Entrez ID		10155	1029
HPRD ID		03445	02542
Ensembl ID		ENSG00000130726	ENSG00000147889
Uniprot IDs		Q13263	K7PML8 P42771 Q8N726
PDB IDs		1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1	1A5E 1BI7 1DC2 2A5E
Enriched GO Terms of Interacting Partners?
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