LAMTOR1 and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 29053956)
17

Data Source:
BioGRID (two hybrid)

		LAMTOR1	TRIM14
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	tripartite motif containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Late Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Membrane Raft Extracellular Exosome Ragulator Complex Ficolin-1-rich Granule Membrane	Mitochondrial Outer Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Binding Molecular Adaptor Activity	Molecular_function Zinc Ion Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Receptor Recycling Endosome Organization Lysosome Organization Cell Cycle Arrest Regulation Of Cholesterol Esterification Regulation Of Cholesterol Efflux Endosomal Transport Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Lysosome Localization Cellular Protein Localization Cholesterol Homeostasis Neutrophil Degranulation Positive Regulation Of MAPK Cascade Regulation Of Cholesterol Import Cellular Response To Amino Acid Stimulus	Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1	Interferon gamma signaling
Drugs
Diseases
GWAS			Multiple sclerosis ( 31604244)
Interacting Genes		5 interacting genes: ABCF3 CAPN1 CCDC90B EEF1A1 TRIM14	52 interacting genes: ABCF3 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H CENPC CSPP1 EIF3G ETFBKMT FAT1 HERC3 ITM2A IVNS1ABP KAT2B KIF3A LAMTOR1 MITD1 MNAT1 MRPL24 NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR2G PPP2R3C RAB5A RAB9A RBM33 RLF RNF125 RNF20 SMARCB1 SMIM3 STK38 TAX1BP1 TMEM167A UBE2B UBE2N UNK WDR35 WRNIP1 ZC4H2 ZFP36L2 ZNF652
Entrez ID		55004	9830
HPRD ID		07933	05948
Ensembl ID		ENSG00000149357	ENSG00000106785
Uniprot IDs		Q6IAA8	A0A024R165 Q14142
PDB IDs		5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG
Enriched GO Terms of Interacting Partners?
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