ACTN3 and PLEKHG2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ACTN3	PLEKHG2
Description		actinin alpha 3 (gene/pseudogene)	pleckstrin homology and RhoGEF domain containing G2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome	Cytosol
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Ion Channel Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Nephrin family interactions Striated Muscle Contraction	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		17 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A BRCA1 C1orf94 KCTD6 MYPN NEBL NRAP PLEKHG2 REL RNF111 SUMO1P1 TRAF1 TRAF2	7 interacting genes: ACTN3 APP CDC42 GNG2 RAC1 RHOA XRN1
Entrez ID		89	64857
HPRD ID		02148	15148
Ensembl ID		ENSG00000248746	ENSG00000090924
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	Q9H7P9
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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