CTSA and NEU1

Number of citations of the paper that reports this interaction (PubMedID 9501080)
24

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro, in vivo)

		CTSA	NEU1
Description		cathepsin A	neuraminidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Lumenal Side Of Lysosomal Membrane	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Specific Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity	Exo-alpha-sialidase Activity Protein Binding Alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity
	Biological Process	Proteolysis Glycosphingolipid Metabolic Process Intracellular Protein Transport Regulation Of Protein Stability Positive Regulation Of Catalytic Activity Neutrophil Degranulation Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Neutrophil Degranulation
Pathways		Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation	Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs			Oseltamivir
Diseases		Galactosialidosis	Sialidosis; Mucolipidosis I Galactosialidosis Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Blood protein levels ( 28240269) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: GLB1 LAMP2 LMNA NEU1	18 interacting genes: CDC42SE2 CREB3 CTSA EEF1A1 ERRFI1 GLB1 IGF1 JUNB KCNA2 KCNA4 LIG4 LMNA MAF MSH5 NFYA NOTCH4 PBX2 SLC17A2
Entrez ID		5476	4758
HPRD ID		02020	09751
Ensembl ID		ENSG00000064601	ENSG00000204386
Uniprot IDs		B4E324 P10619 X6R5C5 X6R8A1	Q5JQI0 Q99519
PDB IDs		1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT
Enriched GO Terms of Interacting Partners?
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