MARCHF5 and MFN2

Number of citations of the paper that reports this interaction (PubMedID 16936636)
156

Data Source:
HPRD (in vitro, in vivo)

		MARCHF5	MFN2
Description		membrane associated ring-CH-type finger 5	mitofusin 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cytoskeleton Integral Component Of Membrane Intrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding GTPase Binding	GTPase Activity Protein Binding GTP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Protein Autoubiquitination Protein Localization To Mitochondrion Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging	Blastocyst Formation Protein Targeting To Mitochondrion Apoptotic Process Response To Unfolded Protein Mitochondrial Membrane Organization Cell Cycle Arrest Blood Coagulation Mitochondrial Fusion Macroautophagy Protein Localization To Phagophore Assembly Site Negative Regulation Of Ras Protein Signal Transduction Camera-type Eye Morphogenesis Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways			Pink/Parkin Mediated Mitophagy Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Inflammatory skin disease ( 25574825) Plasma homocysteine levels ( 30339177) Platelet count ( 22139419) Tuberculosis ( 29036319)
Interacting Genes		19 interacting genes: AKTIP CREB3 FATE1 FIS1 FUNDC1 MAP1B MFN2 SOD1 TANK UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN	4 interacting genes: MARCHF5 PITRM1 PRKN VCP
Entrez ID		54708	9927
HPRD ID		07909	08495
Ensembl ID		ENSG00000198060	ENSG00000116688
Uniprot IDs		Q9NX47	O95140
PDB IDs			6JFK 6JFL 6JFM
Enriched GO Terms of Interacting Partners?
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