MFN2 and PITRM1

		MFN2	PITRM1
Description		mitofusin 2	pitrilysin metallopeptidase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cytoskeleton Integral Component Of Membrane Intrinsic Component Of Mitochondrial Outer Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	GTPase Activity Protein Binding GTP Binding Ubiquitin Protein Ligase Binding	Metalloendopeptidase Activity Enzyme Activator Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Blastocyst Formation Protein Targeting To Mitochondrion Apoptotic Process Response To Unfolded Protein Mitochondrial Membrane Organization Cell Cycle Arrest Blood Coagulation Mitochondrial Fusion Macroautophagy Protein Localization To Phagophore Assembly Site Negative Regulation Of Ras Protein Signal Transduction Camera-type Eye Morphogenesis Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Proteolysis Protein Targeting To Mitochondrion Positive Regulation Of Catalytic Activity
Pathways		Pink/Parkin Mediated Mitophagy Factors involved in megakaryocyte development and platelet production	Mitochondrial protein import
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Inflammatory skin disease ( 25574825) Plasma homocysteine levels ( 30339177) Platelet count ( 22139419) Tuberculosis ( 29036319)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)
Interacting Genes		4 interacting genes: MARCHF5 PITRM1 PRKN VCP	9 interacting genes: BID DPT IDI1 LARP4B MFN2 PNLIPRP1 S100A7 SOCS6 WDR77
Entrez ID		9927	10531
HPRD ID		08495	07142
Ensembl ID		ENSG00000116688	ENSG00000107959
Uniprot IDs		O95140	Q5JRX3
PDB IDs		6JFK 6JFL 6JFM	4L3T 4NGE 4RPU
Enriched GO Terms of Interacting Partners?
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