MTMR12 and MTM1

Number of citations of the paper that reports this interaction (PubMedID 12847286)
29

Data Source:
HPRD (in vitro)

		MTMR12	MTM1
Description		myotubularin related protein 12	myotubularin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Sarcoplasmic Reticulum Sarcomere	Ruffle Cell Cytoplasm Late Endosome Cytosol Plasma Membrane Filopodium I Band
	Molecular Function	Protein Binding Phosphatase Regulator Activity	Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Intermediate Filament Binding Phosphatidylinositol Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Regulation Of Catalytic Activity Toxin Transport	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Endosome To Lysosome Transport Protein Transport Negative Regulation Of TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Peptidyl-tyrosine Dephosphorylation Regulation Of Vacuole Organization Intermediate Filament Organization Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Mitochondrion Distribution Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Protein Kinase B Signaling Mitochondrion Morphogenesis Negative Regulation Of Autophagosome Assembly
Pathways		Synthesis of PIPs at the early endosome membrane	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases			Centronuclear myopathy
GWAS		Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834)
Interacting Genes		1 interacting genes: MTM1	2 interacting genes: KMT2A MTMR12
Entrez ID		54545	4534
HPRD ID		05933	02331
Ensembl ID		ENSG00000150712	ENSG00000171100
Uniprot IDs		Q9C0I1	A0A024RC06 Q13496
PDB IDs
Enriched GO Terms of Interacting Partners?
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