MTM1 and MTMR12

Number of citations of the paper that reports this interaction (PubMedID 12847286)
29

Data Source:
HPRD (in vitro)

		MTM1	MTMR12
Description		myotubularin 1	myotubularin related protein 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Cell Cytoplasm Late Endosome Cytosol Plasma Membrane Filopodium I Band	Cytoplasm Cytosol Sarcoplasmic Reticulum Sarcomere
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Intermediate Filament Binding Phosphatidylinositol Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Protein Binding Phosphatase Regulator Activity
	Biological Process	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Endosome To Lysosome Transport Protein Transport Negative Regulation Of TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Peptidyl-tyrosine Dephosphorylation Regulation Of Vacuole Organization Intermediate Filament Organization Muscle Cell Cellular Homeostasis Phosphatidylinositol Dephosphorylation Mitochondrion Distribution Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Protein Kinase B Signaling Mitochondrion Morphogenesis Negative Regulation Of Autophagosome Assembly	Phosphatidylinositol Biosynthetic Process Regulation Of Catalytic Activity Toxin Transport
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane	Synthesis of PIPs at the early endosome membrane
Drugs
Diseases		Centronuclear myopathy
GWAS			Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834)
Interacting Genes		2 interacting genes: KMT2A MTMR12	1 interacting genes: MTM1
Entrez ID		4534	54545
HPRD ID		02331	05933
Ensembl ID		ENSG00000171100	ENSG00000150712
Uniprot IDs		A0A024RC06 Q13496	Q9C0I1
PDB IDs
Enriched GO Terms of Interacting Partners?
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